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Literature summary extracted from

  • Pfeifer, V.; Nicholson, G.J.; Ries, J.; Recktenwald, J.; Schefer, A.B.; Shawky, R.M.; Schröder, J.; Wohlleben, W.; Pelzer, S.
    A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (2001), J. Biol. Chem., 276, 38370-38377.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.246 expressed in Streptomyces lividans Amycolatopsis mediterranei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.246 4 malonyl-CoA Amycolatopsis mediterranei the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.246 Amycolatopsis mediterranei Q939X3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.246 4 malonyl-CoA
-
 Amycolatopsis mediterranei (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
-
 ?
2.3.1.246 4 malonyl-CoA the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin Amycolatopsis mediterranei (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.246 dpgA
-
 Amycolatopsis mediterranei

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.246 30
-
 assay at Amycolatopsis mediterranei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.246 7.5
-
 assay at Amycolatopsis mediterranei

General Information

EC Number General Information Comment Organism
2.3.1.246 malfunction inactivation of dpgA results in loss of balhimycin production, and restoration is achieved by supplementation with 3,5-dihydroxyphenylacetate Amycolatopsis mediterranei
2.3.1.246 physiological function the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin Amycolatopsis mediterranei